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Buffalo Bills vs. San Francisco 49ers: Weather and Injuries to Impact Sunday Night Football Showdown

The Buffalo Bills will face off against the San Francisco 49ers tonight at Highmark Stadium in Orchard Park, N.Y., in what promises to be a thrilling Sunday Night Football game. While the weather, with potential heavy snow due to a lake-effect storm, has garnered much attention, injuries to key players are also expected to play a significant role in the outcome of this contest.

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The weather conditions in Orchard Park have been a major talking point leading up to tonight’s game. Heavy snow due to a lake-effect storm is expected to create challenging conditions, which could affect both teams’ offensive strategies and overall play. The cold, snow-covered field may favor the running game, potentially putting pressure on quarterbacks Josh Allen of the Bills and Brock Purdy of the 49ers to adjust their passing approaches. However, it is the injuries on both teams that will be crucial in determining who comes out on top.

Bills’ Inactives and Injury Updates

The Buffalo Bills are dealing with a relatively light injury report, though they are still missing some important players. Tight end Dalton Kincaid will not suit up due to a knee injury, while wide receiver Keon Coleman (wrist) and linebacker Matt Milano (bicep) are both questionable for the game. Despite these absences, the Bills’ roster remains strong, with Josh Allen leading the charge at quarterback and key defenders like Greg Rousseau and Damar Hamlin ready to make an impact.

49ers’ Inactives and Injury News

The San Francisco 49ers, however, have a more extensive injury list. The team will be without star players including left tackle Trent Williams, pass rusher Nick Bosa, and cornerback Deommodore Lenoir. Additionally, linebacker Demetrius Flannigan-Fowles, and defensive lineman Jordan Elliott are also inactive. The absence of Williams and Bosa significantly impacts both the 49ers’ offensive and defensive lines. Without Williams, San Francisco’s offense drops from 11th to 16th in expected points added (EPA), a significant dip for a team with Super Bowl aspirations. Similarly, Bosa’s absence is felt heavily on the defense, which will struggle without his pressure on opposing quarterbacks.

Adding to the 49ers’ concerns, quarterback Brock Purdy is listed as questionable, although he is expected to play. Meanwhile, linebacker Fred Warner will be playing through a fractured ankle, making him less than 100% for the game.

Impact on the Game

The injuries to key players on both sides mean that this game could come down to which team can adapt better to the changing conditions. For the 49ers, the loss of Bosa and Williams will be particularly felt. Bosa’s absence has already caused the 49ers’ defense to drop from 16th to 30th in several defensive metrics. The Bills, on the other hand, are in a better position with fewer notable injuries, but they must cope with the potential snowstorm and adjust their strategy accordingly.

Projected Lineups

Despite the injuries, both teams are expected to field strong lineups. The Bills will start Josh Allen at quarterback, with James Cook in the backfield and Amari Cooper, Khalil Shakir, and Keon Coleman at wide receiver. On defense, players like Greg Rousseau and Ed Oliver will need to step up in the absence of Milano.

For the 49ers, Brock Purdy is expected to lead the offense, with Christian McCaffrey in the backfield and Deebo Samuel and Jauan Jennings at receiver. The defense will look to players like Fred Warner and Charvarius Ward to hold the line in the face of Buffalo’s offensive firepower.